Definition
Osler-Weber-Rendu syndrome is an inherited disorder of the blood vessels that can cause excessive bleeding.
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Alternative Names
Hereditary hemorrhagic telangiectasia; HHT
Causes, incidence, and risk factors
Osler-Weber-Rendu syndrome is a condition passed down through families. It results from a problem in one of a few genes. Scientists have identified some of the genes involved. However, they do not know exactly how the gene defects lead to problems seen in persons with this syndrome.
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Symptoms
People with Osler-Weber-Rendu syndrome can develop abnormal blood vessels called arteriovenous malformations (AVMs) in several areas of the body.
If they are on the skin, they are called telangiectasias. The abnormal blood vessels can also develop in the brain, lungs, liver, intestines, or other areas.
Symptoms of this syndrome include:
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GI bleeding, including loss of blood in the stool or dark black stools
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Shortness of breath
Signs and tests
An experienced health care provider can detect telangiectases during a physical examination. There is often a family history of hereditary hemorrhagic telangiectasia.
Signs include:
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Abnormal blood vessels that bleed easily in the throat, bowels, or airways
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Decreased oxygen levels in the blood
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Tests include:
Genetic testing may be available to look for changes in genes associated with this syndrome.
Treatment
Treatments include:
Some patients respond to estrogen therapy, which can reduce bleeding episodes. Avoid taking blood-thinning medications.
Some patients may need to take antibiotics before having dental work or surgery. Ask your doctor what precautions you should take.
Support Groups
HHT Foundation International -- www.hht.org
Expectations (prognosis)
People with this syndrome can live a completely normal lifespan, depending on the parts of the body where the AVMs are located.
Complications
Calling your health care provider
Call your health care provider if your child has frequent nose bleeds or other signs of this disease.
Prevention
Genetic counseling is recommended for couples who want to have children and who have a family history of hereditary hemorrhagic telangiectasia. Medical treatments can prevent certain types of strokes and heart failure.
References
Azuma H: Genetic and molecular pathogenesis of hereditary hemorrhagic telangiectasia. J Med Invest. 2000 Aug; 47(3-4): 81-90.
Faughnan ME, Hyland RH, Nanthakumar K, Redelmeier DA: Screening in hereditary hemorrhagic telangiectasia patients. Chest. 2000 Aug; 118(2): 566-7.
Govani FS, Shovlin CL. Hereditary haemorrhagic telangiectasia: a clinical and scientific review. Eur J Hum Genet. 2009 Apr 1. [Epub ahead of print]
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