Acrodysostosis is an extremely rare disorder that is present at birth (congenital). It leads to problems with the bones of the hands, feet, and nose, and intellectual disability.
Arkless-Graham; Acrodysplasia; Maroteaux-Malamut
Causes, incidence, and risk factors
Most patients with acrodysostosis have no family history of the disease. However, sometimes the condition is passed down from parent to child. Parents with the condition have a 1 in 2 chance of passing the disorder to their children.
There is a slightly greater risk with fathers who are older.
- Frequent middle ear infections
- Growth problems, short arms and legs
- Hearing problems
- Mental deficiency
- Unusual looking face
Signs and tests
Your health care provider can usually diagnose this condition with a physical exam.
This may show:
Advanced bone age
Bone deformities in hands and feet
Delays in growth
Problems with the skin, genitals, teeth, and skeleton
Short arms and legs with small hands and feet
Short head, measured front to back (brachycephaly)
Small, upturned broad nose with flat bridge
Unusual features of the face (short nose, open mouth, jaw that sticks out)
Wide-spaced eyes (hypertelorism), sometimes with extra skin fold at corner of eye
In the first months of life, x-rays may show spotty calcium deposits, called stippling, in bones (especially the nose). Infants may also have:
Treatment depends on the symptoms.
Orthopedic care, early intervention, and special education are recommended.
Problems depend on the degree of skeletal involvement and intellectual disability. In general, patients do relatively well.
Calling your health care provider
Call your health care provider if your infant or child does not seem to be growing or developing properly.
Genetic counseling may be helpful.
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