Candesartan Cilexetil (kan-de-SAR-tan sye-LEX-e-til), Hydrochlorothiazide (hye-droe-klor-oh-THYE-a-zide)
Treats high blood pressure. A lower blood pressure will reduce the risk of stroke and heart attack. This medicine is a combination of an angiotensin receptor blocker and a thiazide diuretic (water pill).
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
Do not use this medicine if you have had an allergic reaction to candesartan, hydrochlorothiazide, or a sulfonamide (sulfa drug). Do not use this medicine if you are pregnant or not able to urinate.
How to Use This Medicine
- Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
- This medicine should not be the first medicine you use to treat your condition. It is meant to be used only after you have tried other medicines that have not worked or have caused unwanted side effects.
- Carefully follow your doctor's instructions about any special diet.Be sure to drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using other blood pressure medicines, including diuretics or water pills such as furosemide, metolazone, spironolactone, triamterene, Aldactone®, Demadex®, Lasix®, Lozol®, Maxzide®, or Zaroxolyn®.
- Make sure your doctor knows if you are also using lithium (Eskalith®, Lithobid®), digoxin (Lanoxin®), norepinephrine, insulin or a diabetes medicine that you take by mouth (such as glipizide, glyburide, metformin, Actos®, Amaryl®, Avandia®, Glucotrol®, or Glucophage®), medicine to lower your cholesterol (such as cholestyramine, colestipol, Colestid®, or Questran®), a steroid medicine (such as cortisone, dexamethasone, prednisolone, prednisone, or Medrol®), muscle relaxers (such as tubocurarine), or pain or arthritis medicine or NSAIDs (such as aspirin, celecoxib, ibuprofen, naproxen, rofecoxib, valdecoxib, Advil®, Aleve®, Bextra®, Celebrex®, Motrin®, Orudis®, Relafen®, or Vioxx®).
- Do not use medicines, supplements, or salt substitutes that contain potassium without first checking with your doctor.
- Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you drink alcohol or use pain relievers or sleeping pills.
Warnings While Using This Medicine
- Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
- Make sure your doctor knows if you are breastfeeding, or if you have kidney problems, liver disease, edema or body swelling, heart or blood vessel disease, congestive heart failure, low blood pressure, high cholesterol or triglycerides, or a mineral imbalance (such as high or low calcium, magnesium, potassium, or sodium in the blood). Tell your doctor if you have diabetes, gout, lupus, allergies, or a history of asthma.
- This medicine could lower your blood pressure too much and cause you to feel dizzy or lightheaded. Stand or sit up slowly if you are dizzy. This is more likely to happen when you begin to use the medicine. It could also happen if you have diarrhea or vomiting, you sweat heavily, or you do not drink enough water and become dehydrated. If you faint, stop using this medicine until you have talked to your doctor.
- Check with your doctor right away if you have confusion, muscle pain or cramps, nausea and vomiting, trouble breathing, weakness, or an uneven heartbeat. These could be symptoms of electrolyte imbalances (too little sodium, potassium, or magnesium).
- Check with your doctor immediately if blurred vision, eye pain, or any other change in vision occurs. Your doctor may want an eye doctor to check your eyes.
- This medicine may raise your blood sugar. You should check your blood sugar more often during the first month you take this medicine, and then on a regular basis.
- Even if you feel well, do not stop using this medicine without asking your doctor. This medicine will not cure your high blood pressure, but it will help keep it in normal range. You may have to take blood pressure medicine for the rest of your life.
- Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blurred vision and eye pain
- Change in how much or how often you urinate, or problems urinating
- Chest pain
- Confusion, body weakness, and muscle twitching
- Dark-colored urine or pale stools
- Dry mouth, increased thirst, or muscle cramps
- Fast, slow, or pounding heartbeat
- Lightheadedness, dizziness, or fainting
- Nausea, vomiting, loss of appetite, or stomach pain
- Swelling in your hands, ankles, or feet
- Unusual tiredness or weakness
- Yellowing of your skin or the whites of your eyes
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
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