Treats high amounts of methotrexate in the blood of patients who have severe kidney disease.
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
You should not receive this medicine if you have had an allergic reaction to glucarpidase.
How to Use This Medicine
- Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
- A nurse or other trained health professional will give you this medicine.
- Drink extra fluids so you will pass more urine while you are using this medicine. This will keep your kidneys working well and help prevent kidney problems.
If a dose is missed:
- Only 1 dose of this medicine will be given.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Leucovorin should not be given within 2 hours of this medicine.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or breastfeeding.
- Tell your nurse or doctor right away if you have an infusion reaction. Some symptoms might be fever, chills, rash, hives, itching, headache, tingling, or numbness. You might also feel hot, or your throat may feel tight or swollen.
- Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Lightheadedness, dizziness, or fainting
If you notice these less serious side effects, talk with your doctor:
- Diarrhea, nausea, or vomiting
- Numbness, tingling, or burning pain in your hands, arms, legs, or feet
- Warmth or redness in your face, neck, arms, or upper chest
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition.
- A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions.
- Call 911 for all medical emergencies.
- Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.
©1997 - A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.