Alternate Names :
Corticosteroid drugs (also known as glucocorticoids) act like the naturally occurring adrenal hormone cortisone in the body. They are strong anti-inflammatory and immune-suppressant medications used in many inflammatory and autoimmune conditions, such as rheumatoid arthritis , asthma , inflammatory bowel disease , and systemic lupus erythematosus . Corticosteroids are also prescribed to suppress transplant rejection.
Drugs in this family include:
- Betamethasone (Celestone)
- Cortisone acetate (Cortone Acetate)
- Dexamethasone (Decadron, Dexameth, Dexone, Hexadrol)
- Hydrocortisone (Cortef, Hydrocortone)
- Methylprednisolone (Medrol)
- Prednisolone (Delta-Cortef, Pediapred, Prelone)
- Prednisone (Deltasone, Liquid Pred, Meticorten, Orasone, Panasol-S, Prednicen-M, Sterapred DS)
- Triamcinolone (Aristocort, Atolone, Kenacort)
- And others
One of the most serious side effects of long-term corticosteroid use is accelerated osteoporosis. Although we don't fully understand how this works, corticosteroid interference with calcium and vitamin D is known to play a major role.
Calcium and vitamin D supplements are definitely beneficial for fighting ordinary osteoporosis ; in addition, there is good evidence that they also protect against osteoporosis brought on by corticosteroids. 1 A review of 5 trials enrolling a total of 274 participants found that calcium and vitamin D supplementation significantly prevented bone loss at the lumbar spine and forearm in corticosteroid-treated individuals. 2 For example, in a 2-year double-blind placebo-controlled study of 130 individuals, supplementation with 1,000 mg of calcium and 500 IU of vitamin D daily actually reversed steroid-induced bone loss, causing a net bone gain. 3
There are theoretical reasons (but little direct evidence) to believe that individuals taking corticosteroids, such as prednisone, might be protected from some side effects by taking DHEA at the same time. 9,10
Long-term, high-dose corticosteroid treatment can cause diabetes. This may be at least partly caused by chromium deficiency. A very preliminary study found treatment with corticosteroids caused increased loss of chromium in the urine. 11 Another preliminary study found that individuals with corticosteroid-induced diabetes could improve blood sugar control by taking chromium supplements. 12
Long-term use of corticosteroids, whether orally, or possibly, by inhalation, can slow a child’s growth. One animal study suggests that use of the supplement creatine may help prevent this side effect. 15
The supplement ipriflavone is used to treat osteoporosis. A 3-year, double-blind trial of almost 500 women, as well as a small study, found worrisome evidence that ipriflavone can reduce white blood cell count in some people. 13,14 For this reason, anyone taking medications that suppress the immune system should avoid using ipriflavone except under physician supervision.
When taken by mouth, the herb licorice appears to enhance some actions of oral corticosteroids, but interfere with others. 6-8 Because of the unpredictable nature of this interaction, individuals using oral corticosteroids should avoid licorice.
- EBSCO CAM Review Board
- Reviewed: 09/2014
- Updated: 09/18/2014
Please note, not all procedures included in this resource library are available at Allegiance Health or performed by Allegiance Health physicians.
All EBSCO Publishing proprietary, consumer health and medical information found on this site is accredited by URAC. URAC's Health Web Site Accreditation Program requires compliance with 53 rigorous standards of quality and accountability, verified by independent audits. To send comments or feedback to our Editorial Team regarding the content please email us at HLEditorialTeam@ebscohost.com.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.