Estrogen is used as a component of birth control pills, as well as for preventing osteoporosis and heart disease in menopausal women.
Some estrogen products contain the hormone in different forms. For example, certain products such as Ortho Dienestrol Vaginal Cream contain estrogen as dienestrol. Medications containing a form of estrogen called estradiol include:
- Delestrogen (injectable)
- DepGynogen (injectable)
- Depo-Estradiol Cypionate (injectable)
- Depogen (injectable)
- Estra-L (injectable)
- Gynogen L.A. (injectable)
- Valergen (injectable)
- and others
Premarin, Cenestin, Prempro, and Premphase contain another form of estrogen called conjugated estrogens. Other forms of estrogen and some of their brand names include diethylstilbestrol diphosphate (Stilphostrol), estrone (Kestrone-5), esterified estrogens (Estratab, Menest), estropipate (Ogen, Ortho-Est), and ethinyl estradiol (Estinyl) among others.
Some evidence suggests that estrogen may interfere with the absorption of folate. 1 Since folate deficiency is fairly common even among those not taking estrogen, taking a folate supplement on general principle is probably a good idea.
When the two are taken together, ipriflavone may increase estrogen's ability to protect bone. 2-6 This may allow you to use a lower dose of estrogen and still receive its beneficial effects.
However, there may be risks involved. Although ipriflavone itself probably does not affect tissues other than bone, some evidence suggests that when it is combined with estrogen, estrogen's effects on the uterus are increased. 7,8 This might mean that risk of uterine cancer would be elevated by the combination.
It should be possible to overcome this risk by taking progesterone along with estrogen, which is standard medical practice. However, this finding does make one wonder whether ipriflavone-estrogen combinations raise the risk of breast cancer as well, an estrogen side effect that has no easy solution. At present, there is no available information on this important subject.
In some studies, boron has been found to elevate levels of the body's own estrogen. 11,12 This might lead to an increased risk of estrogen side effects if boron is combined with estrogen therapy.
The supplement resveratrol has a chemical structure similar to that of the synthetic estrogen diethylstilbestrol and produces estrogenic-like effects. 14 For this reason, it should not be combined with prescription estrogen products.
Weak evidence hints that the herb rosemary may enhance the liver’s rate of deactivating estrogen in the body. 20 This could potentially interfere with the activity of medications that contain estrogen.
Indole-3-carbinol (I3C) is a substance found in broccoli that is thought to have cancer preventive effects. One of its mechanisms of action is thought to involve facilitating the inactivation of estrogen, as well as blocking its effects on cells. 13,17-18 The net result could be decreased effectiveness of medications containing estrogen.
Because of its effects on the pituitary gland, chasteberry might unpredictably alter the effects of estrogen-replacement therapy.
The herb dong quai (Angelica sinensis) is used for menstrual disorders.
Because dong quai contains beta-sitosterol, a phytoestrogen, 15 there have been concerns that taking the herb with estrogen might add to estrogen-related side effects. However, a 24-week, placebo-controlled study of 74 postmenopausal women found no estrogen-like effects or reduction of menopausal symptoms associated with taking dong quai. 16
Therefore, dong quai seems unlikely to increase estrogen-related side effects.
- EBSCO CAM Review Board
- Reviewed: 12/2015
- Updated: 12/15/2015
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