Gilbert syndrome is a genetic liver disorder. It causes levels of bilirubin to rise above normal levels. Bilirubin is a yellow chemical by-product of hemoglobin. Hemoglobin is the red pigment in blood cells that is usually excreted by the liver as bile.
|Copyright © Nucleus Medical Media, Inc.|
Gilbert syndrome is usually caused by an inherited genetic abnormality. Symptoms occur when there is an interference with the liver enzyme that is important in the elimination of bilirubin. This causes the levels of bilirubin to increase in the blood, which may produce symptoms such as jaundice .
Gilbert syndrome is more common in males, and in those with a family history.
Often, there are no symptoms of Gilbert syndrome. However, people who do have symptoms may experience:
- Yellowing of the skin known as jaundice
- Jaundice of the whites of the eyes
- Abdominal pain
- Loss of appetite
- Fatigue and weakness
- Darkening of the urine
Your doctor will ask about your symptoms and medical history. A physical exam will be done. Tests may include:
- Blood tests
- Reticulocyte count
- Total and direct bilirubin
- Liver function tests
No treatment is necessary for Gilbert syndrome. Usually, symptoms come and go.
There is no way to prevent Gilbert syndrome. However, you may prevent symptoms by avoiding the following:
- Skipping meals or fasting
- Vigorous exercise
- Repeated bouts of vomiting
- Stress or trauma
- Michael Woods, MD
- Reviewed: 02/2015
- Updated: 03/18/2013
All EBSCO Publishing proprietary, consumer health and medical information found on this site is accredited by URAC. URAC's Health Web Site Accreditation Program requires compliance with 53 rigorous standards of quality and accountability, verified by independent audits. To send comments or feedback to our Editorial Team regarding the content please email us at HLEditorialTeam@ebscohost.com.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.