Periodic Paralysis Syndromes

Definition

Periodic paralysis is a rare groups of conditions. It causes occasional episodes of severe muscle weakness. The most common types of periodic paralysis are hypokalemic, hyperkalemic and Andersen-Tawil syndrome. Less common forms include paramyotonia congenita von Eulenburg, thyrotoxic, distal renal tubular acidosis, X-linked episodic muscle weakness syndrome, and congenital myasthenic syndromes.

Causes

Periodic paralysis is a condition that is present from birth. Elements in the body are needed to make the muscles contract. With periodic paralysis, the gateway for these elements are disturbed and disrupt the ability to contract.

Familial periodic paralysis is inherited, but may occur without a known family history. With the inherited form of the disorder, only 1 affected parent is needed to transmit the gene to the baby. Rarely, the condition occurs as a result of a noninherited genetic defect.

Genetic Material
Chromosome DNA
Copyright © Nucleus Medical Media, Inc.

Risk Factors

Factors that increase your chance of developing periodic paralysis include:

  • Family history of periodic paralysis
  • Thyroid disorder—high thyroid hormone levels, particularly in Asian males

Symptoms

Episodes of severe weakness in the arms and legs are the main symptom. Typically, these episodes occur during sleep, early morning, or after strenuous activity. Cold, stress, and alcohol may also produce attacks. Other, less common, symptoms may include:

  • Weakness in the eyelids and face muscles
  • Muscle pain
  • Irregular heartbeats, especially with Andersen-Tawil syndrome
  • Difficulty breathing or swallowing—requires emergency care

Although muscle strength returns to normal between attacks, repeated episodes of weakness may lead to chronic muscle weakness later in life.

Some features are specific to the type of periodic paralysis.

  • Hypokalemic (due to low potassium levels in the body):
    • Frequency of attacks varies from daily to yearly
    • Attacks usually last between 4-24 hours, but can last for several days
  • Hyperkalemic (due to high potassium levels in the body):
    • Attacks are usually shorter, more frequent, and less severe than the hypokalemic form; breathing and swallowing difficulties are rare
    • Between attacks, patients often experience muscle spasms or difficulty relaxing their muscles, a condition is known as myotonia
  • Andersen-Tawil
    • Attacks may last 1 hour to several days and weakness may persist after attacks
    • Associated with some abnormal facial features

Persons with some types of periodic paralysis are at risk for a condition known as malignant hyperthermia . This can occur during the use of general anesthesia . Anyone with a family history of periodic paralysis needs to notify the anesthesiologist of this history prior to any surgery.

Diagnosis

Because this primarily is an inherited condition, the most important part of diagnosis is obtaining a family history. You will be asked about your symptoms and your medical history. A physical exam will be done.

Your doctor may want to bring on an attack during an office visit. This should only be done under careful monitoring by an experienced neurologist. If an attack is triggered, several tests may be done, including:

Your muscle tissue may need to be tested. This can be done with a biopsy .

Electromyography (EMG)
Electromyogram EMG
Copyright © Nucleus Medical Media, Inc.

Treatment

Since there is no cure for periodic paralysis, lifelong treatment is usually required. Treatment focuses on preventing attacks and relieving symptoms.

Lifestyle Changes

Dietary changes can help influence the level of potassium in the body. Depending on your situation, you may be referred to a dietitian for help with meal planning.

You may also be advised to avoid strenuous exercise and drinking alcohol. They could make symptoms worse.

Medications

The type of medications prescribed depend on the type of periodic paralysis.

  • Medications for hypokalemic, hyperkalemic, and Andersen Tawil syndrome include:
    • Acetazolamide—may prevent an attack by reducing the flow of potassium from the bloodstream into the cells of the body.
    • Diuretics (water pills)
    • Drugs to control abnormal heart beats
  • Hypokalemic:
    • Potassium may stop an attack; IV potassium may be prescribed for severe weakness
    • Avoiding certain commonly prescribed medications may help reduce the onset of attacks.
    • If you have a thyroid condition, be sure to get treatment for it.
  • Hyperkalemic:
    • Thiazide diuretics, or water pills, may be prescribed to prevent an attack.
    • Glucose and insulin, or calcium carbonate may be prescribed to slow or stop an attack.

Prevention

Familial periodic paralysis cannot be prevented. Because it can be inherited, genetic counseling may be advised for couples at risk of passing on the disorder.

Revisions

Please note, not all procedures included in this resource library are available at Henry Ford Allegiance Health or performed by Henry Ford Allegiance Health physicians.

All EBSCO Publishing proprietary, consumer health and medical information found on this site is accredited by URAC. URAC's Health Web Site Accreditation Program requires compliance with 53 rigorous standards of quality and accountability, verified by independent audits. To send comments or feedback to our Editorial Team regarding the content please email us at HLEditorialTeam@ebscohost.com.

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.

Editorial Policy | Privacy Policy | Terms and Conditions | Support
Copyright © 2008 EBSCO Publishing. All rights reserved.

Making lifestyle changes, such as avoiding problematic foods or starting a new bedtime routine, may help reduce the symptoms of your acid reflux.