Hydrochlorothiazide (hye-droe-klor-oh-THYE-a-zide), Spironolactone (spir-on-oh-LAK-tone)
Treats fluid retention (edema) and high blood pressure. This medicine contains 2 diuretic medicines (water pills).
AldactazideThere may be other brand names for this medicine.
When This Medicine Should Not Be Used
Do not use this medicine if you have had an allergic reaction to spironolactone, hydrochlorothiazide, or a sulfonamide (sulfa drug). Do not use this medicine if you are not able to urinate, or if you have Addison disease (an adrenal gland problem), severe kidney disease, or too much calcium or potassium in the blood.
How to Use This Medicine
- Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
- Carefully follow your doctor's instructions about any special diet.Drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting.
If a dose is missed:
- Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using another diuretic (such as triamterene, Dyrenium®) or another medicine that contains spironolactone, such as Aldactone®.
- Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium. You could have high levels of potassium in your blood that would cause serious health problems.
- Make sure your doctor knows if you also use eplerenone (Inspra®), cholestyramine (Questran®), digoxin (Lanoxin®), a blood thinner (such as heparin, dalteparin, enoxaparin, Fragmin®, Lovenox®), lithium (Eskalith®, Lithobid®), an NSAID pain or arthritis medicine (such as aspirin, diclofenac, indomethacin, naproxen, Advil®, Aleve®, Indocin®, Celebrex®, Voltaren®), a steroid medicine (such as hydrocortisone, methylprednisolone, prednisolone, prednisone), other blood pressure medicine (such as benazepril, enalapril, lisinopril, Avalide®, Avapro®, Benicar®, Cozaar®, Diovan®, Lotrel®, Micardis®, Vasotec®, Zestoretic®, Zestril®), or insulin or diabetes medicine that you take by mouth (such as glimepiride, glyburide, metformin, Actos®, Janumet®, Januvia®).
- Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, diabetes, glaucoma, gout, high cholesterol, lupus, a mineral imbalance (such as low calcium, chloride, magnesium, potassium, or sodium in the blood), or a history of asthma or allergies.
- Check with your doctor immediately if you have blurred vision, trouble seeing, eye pain, or any other change in vision. These could be symptoms of glaucoma, which could cause permanent damage to your vision.
- This medicine may cause you to feel dizzy or lightheaded. Stand or sit up slowly if you are dizzy. This is more likely to happen when you begin to use the medicine or if you become dehydrated. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you.
- This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
- Do not stop using the medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in normal range. You may have to take blood pressure medicine for the rest of your life.
- Make sure any doctor or dentist who treats you knows that you are using this medicine.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, or red skin rash
- Blurred vision or vision changes
- Confusion, weakness, uneven heartbeat, trouble breathing, numbness or tingling in your hands, feet, or lips
- Dry mouth, increased thirst, muscle cramps, nausea, vomiting
- Lightheadedness, dizziness, or fainting
- Problems urinating, pain in the side or lower back
- Severe diarrhea
- Unusual bleeding, bruising, or weakness
If you notice these less serious side effects, talk with your doctor:
- Breast swelling, enlargement, pain, or tenderness
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088