Lowers high cholesterol and triglyceride levels in the blood. Lowers risk of heart attack, stroke, and certain blood vessel problems in people with certain risk factors. This medicine is an HMG-CoA inhibitor (statin).
ZocorThere may be other brand names for this medicine.
When This Medicine Should Not Be Used
Do not use this medicine if you have had an allergic reaction to simvastatin. Do not use this medicine if you have active liver disease or if you are pregnant or breastfeeding. Do not use this medicine if you also use any of the following medicines: boceprevir (Victrelis®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), danazol (Danocrine®), gemfibrozil (Lopid®), nefazodone (Serzone®), telaprevir (Incivek®), certain antibiotics (such as clarithromycin, erythromycin, itraconazole, ketoconazole, posaconazole, telithromycin, voriconazole, Nizoral®), or medicines to treat HIV/AIDS (such as atazanavir, indinavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Kaletra®, Lexiva®, Norvir®, Prezista®, Reyataz®).
How to Use This Medicine
- Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
- Take the medicine in the evening, unless your doctor tells you otherwise.
- Carefully follow your doctor's instructions about diet and exercise. This medicine is part of a complete plan for lowering cholesterol and triglycerides in your blood.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you also use amiodarone (Cordarone®), colchicine (Colcrys®), digoxin (Lanoxin®), dronedarone (Multaq®), niacin (Vitamin B3), ranolazine (Ranexa®), certain blood pressure medicines (such as amlodipine, diltiazem, verapamil, Cardizem®, Norvasc®), other medicines for lowering cholesterol (such as fenofibrate, Tricor®), or a blood thinner (such as warfarin, Coumadin®, Jantoven®).
- Tell your doctor if you usually drink more than 2 glasses of alcohol per day or if you drink grapefruit juice.
Warnings While Using This Medicine
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Make sure your doctor knows if you have kidney disease, diabetes, thyroid problems, or muscle pain or weakness. Tell your doctor if you have a history of liver disease, heart disease, or stroke or if you drink alcohol regularly.
- Talk to your doctor if you are Chinese or have Chinese ancestry and take large amounts of niacin (Niacor®, Niaspan®). Chinese patients who take large amounts of niacin (greater than or equal to 1 gram or 1000 milligrams per day) together with this medicine may have an increased risk for muscle injury.
- Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness. These could be symptoms of a serious muscle problem called myopathy.
- Call your doctor right away if you have dark-colored urine, fever, muscle cramps or spasms, muscle pain or stiffness, or unusual tiredness or weakness. These could be symptoms of a serious muscle problem called rhabdomyolysis, which can cause kidney problems.
- Make sure any doctor or dentist who treats you knows that you use this medicine. You may need to stop using this medicine if you have major surgery, a major injury, or you develop other serious health problems.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, peeling, red skin rash
- Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
- Muscle pain, tenderness, or weakness
- Unusual tiredness
If you notice these less serious side effects, talk with your doctor:
- Confusion or problems with memory
- Runny or stuffy nose
- Stomach pain