Amlodipine (am-LOE-di-peen), Benazepril (ben-AZ-e-pril)
Treats high blood pressure. A lower blood pressure can reduce the risk of stroke and heart attack. This medicine contains an angiotensin-converting enzyme (ACE) inhibitor and a calcium channel blocker (CCB).
LotrelThere may be other brand names for this medicine.
When This Medicine Should Not Be Used
Do not use this medicine if you have had an allergic reaction to amlodipine or benazepril. Do not use this medicine if you are pregnant or have a history of angioedema (swelling of the face, lips, tongue, throat, arms, or legs) after receiving an ACE inhibitor. Do not use this medicine together with aliskiren (Tekturna®) if you have diabetes.
How to Use This Medicine
- Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.Take this medicine at the same time each day.
- Carefully follow your doctor's instructions about any special diet. Drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
If a dose is missed:
- If you miss a dose or forget to take your medicine, take it as soon as you can. If more than 12 hours have passed since you missed your last dose, skip the missed dose and take the next dose when you normally would.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using lithium (Eskalith®, Lithobid®), simvastatin (Zocor®), gold injections, a diuretic (water pill, such as amiloride, furosemide, hydrochlorothiazide, spironolactone, triamterene, Aldactone®, Lasix®), insulin or oral diabetes medicine (such as glimepiride, glyburide, metformin, Actos®, Janumet®, Januvia®), or an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®). Tell your doctor if you are also using medicine to treat HIV/AIDS (such as indinavir, ritonavir, Norvir®) or medicine to treat an infection (such as clarithromycin, itraconazole, ketoconazole, Nizoral®).
- Make sure your doctor knows if you are also using another blood pressure medicine (such as aliskiren, enalapril, lisinopril, Avalide®, Avapro®, Benicar®, Cozaar®, Diovan®, Micardis®, Tekturna®, Vasotec®, Zestril®, Zestoretic).
- Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.
Warnings While Using This Medicine
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Make sure your doctor knows if you are breastfeeding, or if you have kidney problems, liver disease, congestive heart failure, heart disease, low blood pressure, diabetes, or a mineral imbalance (such as high potassium or low sodium in the blood).
- Call your doctor right away if you have severe stomach pain (with or without nausea or vomiting). This could be a symptom of intestinal angioedema.
- Call your doctor right away if you have chest pain that is worse than usual; trouble breathing; nausea or vomiting; pain or discomfort in your arms, jaw, back, or neck; fainting; or unusual sweating. This medicine may worsen the symptoms of an existing heart problem.
- This medicine could lower your blood pressure too much and cause you to feel dizzy or lightheaded. Stand or sit up slowly if you are dizzy. This is more likely to happen when you begin to use the medicine or if you become dehydrated.
- Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine could affect surgery or other procedures that involve anesthetics.
- Angioedema and other allergic reactions are rare, but are more common among black patients.
- This medicine may be less effective in black patients.
- Do not stop using this medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Change in how much or how often you urinate
- Chest pain (may be related to your disease and not a side effect)
- Chest pain that spreads to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, or faintness
- Confusion, weakness, trouble breathing, numbness or tingling in your hands, feet, or lips
- Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
- Fast, pounding, or uneven heartbeat
- Lightheadedness, dizziness, fainting
- Rapid weight gain, swelling in your hands, ankles, or feet
- Severe stomach pain (with or without nausea or vomiting)
- Unusual tiredness or weakness
If you notice these less serious side effects, talk with your doctor:
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088