Treats non-small cell lung cancer (NSCLC).
XalkoriThere may be other brand names for this medicine.
When This Medicine Should Not Be Used
Do not use this medicine if you are pregnant.
How to Use This Medicine
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- Take your medicine as directed.
- You may also receive medicines to help prevent nausea and vomiting.
- Swallow the capsule whole. Do not break, crush, chew, or open it.
- Missed dose: If you miss a dose and it is more than 6 hours until your next dose, use it as soon as you can. If your next dose is less than 6 hours away, wait until then to use the medicine and skip the missed dose.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the capsules in the original container.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some medicines and foods can affect how crizotinib works. Tell your doctor if you are using St John's wort, alfentanil, arsenic trioxide, cisapride, cyclosporine, dofetilide, fentanyl, quinidine, sirolimus, or tacrolimus. Also tell your doctor if you are using medicine to treat HIV/AIDS, medicine to treat an infection or tuberculosis, medicine to treat seizures, medicine to treat depression or mental illness, or an ergot medicine.
- Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Warnings While Using This Medicine
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, liver disease, heart disease, congestive heart failure, heart rhythm problems, or a mineral imbalance.
- This medicine may cause the following problems:
- Pneumonitis (may be life-threatening)
- Liver problems
- Heart rhythm problems
- Changes in vision
- This medicine may cause dizziness, tiredness, or vision problems. Do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chest pain
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, or yellow skin or eyes
- Fast, pounding, or uneven heartbeat
- Fever, chills, cough
- Numbness, tingling, or burning pain in your hands, arms, legs, or feet
- Trouble breathing
- Rapid weight gain, swelling in your hands, ankles, or feet
- Unusual bleeding, bruising, or weakness
If you notice these less serious side effects, talk with your doctor:
- Back, muscle, or joint pain
- Changes in vision
- Decreased appetite
- Diarrhea, constipation, nausea, vomiting
- Headache or dizziness
- Runny or stuffy nose, sore throat, and body aches
- Tiredness or trouble sleeping