Emtricitabine (em-trye-SYE-ta-been), Rilpivirine Hydrochloride (ril-pi-VIR-een hye-droe-KLOR-ide), Tenofovir Disoproxil Fumarate (ten-OF-oh-vir dye-soe-PROX-il FUE-ma-rate)
Treats human immunodeficiency virus (HIV) infection. HIV causes acquired immune deficiency syndrome (AIDS). This medicine does not cure HIV or AIDS, but it may slow the progress of the disease.
CompleraThere may be other brand names for this medicine.
When This Medicine Should Not Be Used
Do not use this medicine if you have had an allergic reaction to emtricitabine, rilpivirine, or tenofovir. Do not use this medicine if you also take adefovir (Hepsera®), lamivudine (Combivir®, Epivir®, Epivir-HBV®, Epzicom®, Trizivir®), other medicines that contain emtricitabine, rilpivirine, or tenofovir (such as Atripla®, Edurant®, Emtriva®, Stribild?, Truvada®, Viread®), a seizure medicine (such as carbamazepine, oxcarbazepine, phenobarbital, phenytoin, Dilantin®, Tegretol®, Trileptal®), medicine to treat tuberculosis (such as rifabutin, rifampin, rifapentine, Mycobutin®, Priftin®, Rifadin®, Rimactane®), certain stomach medicines (such as dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole, Aciphex®, Dexilant®, Nexium®, Prevacid®, Prilosec®), dexamethasone (Decadron®), or St John's wort.
How to Use This Medicine
- Take your medicine as directed.
- It is best to take this medicine with food or milk.
- Keep taking this medicine for the full time of treatment, even if you begin to feel better. Do not change or stop using this medicine without checking first with your doctor.
- You should take this medicine every day and try not to miss any doses. Contact your doctor or pharmacist when your supply is running low. Do not allow yourself to run out of medicine.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
If a dose is missed:
- If you miss a dose or forget to use your medicine and it is less than 12 hours since your last dose, take it as soon as you can and take your next dose at the normal time. If you miss a dose or forget to use it, and it is more than 12 hours since your last dose, wait and take your next dose at the normal time. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you use other medicines to treat HIV/AIDS such as acyclovir, cidofovir, ganciclovir, valacyclovir, valganciclovir, Cytovene®, Valcyte®, Valtrex®, Vistide®, or Zovirax®.
- Tell your doctor if you use arsenic trioxide (Trisenox®), cisapride (Propulsid®), dofetilide (Tikosyn®), methadone (Dolophine®), medicine for depression (such as amitriptyline, fluoxetine, nortriptyline, Elavil®, Pamelor®, Prozac®, Sarafem®, Vivactil®), or certain antibiotics (such as clarithromycin, erythromycin, levofloxacin, moxifloxacin, sparfloxacin, telithromycin, troleandomycin, Avelox®, Levaquin®).
- Make sure your doctor knows if you use medicine for a fungus infection (such as fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole, Diflucan®, Nizoral®) or medicine for a mental illness (such as haloperidol, mesoridazine, pimozide, prochlorperazine, quetiapine, thioridazine, ziprasidone, Compazine®, Mellaril®).
- If you take antacids that contain aluminum, magnesium, or calcium, take the antacid at least 2 hours before or 4 hours after you take this medicine.
- If you take a stomach medicine for heartburn or ulcers (such as cimetidine, famotidine, nizatidine, ranitidine, Axid®, Pepcid®, Tagamet®, Zantac®), take the heartburn medicine at least 12 hours before or 4 hours after you take this medicine.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or have kidney problems, liver disease, hepatitis B or C infection, osteoporosis, or a history of depression.
- Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.
- This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.
- This medicine may cause a rare, but serious, condition called lactic acidosis (too much acid in the blood). Call your doctor right away if you have abdominal or stomach discomfort, a loss of appetite, diarrhea, muscle pain or cramping, nausea, trouble breathing, or extreme tiredness or weakness.
- Check with your doctor right away if you have pale stools, dark urine, a loss of appetite, nausea and vomiting, stomach pain, unusual tiredness or weakness, or yellow eyes or skin. These may be symptoms of a serious liver problem.
- Tell your doctor right away if you start to feel depressed and have thoughts about hurting yourself. Report any unusual thoughts or behavior that troubles you, especially if they are new or get worse quickly.
- This medicine may increase your risk for broken bones (fractures). Ask your doctor about this if you have any concerns.
- This medicine may cause changes to your body fat. Tell your doctor if you notice an increased amount of fat in the upper back and neck or around the chest and stomach area. You might also lose fat from your legs, arms, or face.
- Your immune system may get stronger when you start taking HIV medicines. Tell your doctor right away if you notice any changes in your health. Sometimes the immune system will start to fight infections that were hidden in your body, such as pneumonia, herpes, or tuberculosis. Autoimmune disorders such as Graves disease, polymyositis, and Guillain-Barré syndrome may also occur.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Change in how much or how often you urinate
- Dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
- Extreme weakness, tiredness, or confusion
- Feeling sad or depressed, anxious, or restless
- Fever, chills, cough, runny or stuffy nose, sore throat, and body aches
- Lightheadedness, dizziness, fainting
- Trouble breathing
- Unusual thoughts or behavior, thoughts of hurting others or oneself
If you notice these less serious side effects, talk with your doctor:
- Headache, trouble sleeping
- Skin rash
- Weight gain around your neck, upper back, breast, or waist
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088