Acetaminophen (a-seet-a-MIN-oh-fen), Oxycodone Hydrochloride (ox-i-KOE-done hye-droe-KLOR-ide)
Treats moderate to moderately severe pain. This medicine contains a narcotic pain reliever.
Endocet, Magnacet, Percocet, Primalev, Primlev, Roxicet, XoloxThere may be other brand names for this medicine.
When This Medicine Should Not Be Used
Do not use this medicine if you have had an allergic reaction to acetaminophen or oxycodone. You should not use this medicine if you have serious breathing problems (such as severe asthma, hypercarbia, respiratory depression) or paralytic ileus (a serious bowel problem).
How to Use This Medicine
Capsule, Liquid, Tablet
- Take your medicine as directed.
- This medicine contains acetaminophen. Read the labels of all other medicines you are using to see if they also contain acetaminophen, or ask your doctor or pharmacist. Do not use more than 4 grams (4,000 milligrams) total of acetaminophen in one day.
- You may take this medicine with food or milk if it upsets your stomach.
- Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
- Drink plenty of liquids to help avoid constipation.
If a dose is missed:
- If you take this medicine on a regular basis: If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Do not throw any unused medicine in the trash. Flush it down the toilet or take it to a community take-back program when available. You will also need to throw away old medicine after the expiration date has passed.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using butorphanol (Stadol®), nalbuphine (Nubain®), naltrexone (Revia®), pentazocine (Talwin®), muscle relaxants (such as pancuronium, tubocurarine, vecuronium, or Norcuron®), or a phenothiazine medicine (such as prochlorperazine, Compazine®, Phenergan®, Trilafon®, Mellaril®, or Thorazine®).
- Tell your doctor if you are using birth control pills, lamotrigine (Lamictal®), zidovudine (Retrovir®), propanolol (Inderal®), or a diuretic (water pill, such as Lasix®).
- Tell your doctor if you drink alcohol or if you are using any medicine that makes you sleepy, such as allergy medicine or narcotic pain medicine.
- Do not drink alcohol while you are using this medicine. Acetaminophen may damage your liver. Alcohol increases this risk. Tell your doctor if you drink 3 or more alcoholic drinks a day.
- Many combination medicines contain acetaminophen, including products with brand names such as Alka-Seltzer Plus®, Comtrex®, Drixoral®, Excedrin Migraine®, Midol®, Sinutab®, Sudafed®, Theraflu®, and Vanquish®. Carefully check the labels of all other medicines you are using to be sure they do not contain acetaminophen.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, or low blood pressure. Tell your doctor if you have breathing problems or lung disease, especially if you have asthma, COPD (chronic obstructive pulmonary disease), cor pulmonale, kyphoscoliosis (curved spine that causes breathing trouble). Also tell your doctor if you have urination problems, an underactive thyroid, Addison disease, pancreas or prostate problems, or a stomach disorder. Tell your doctor if you have a history of head injury or brain damage, seizures, alcohol or drug abuse. Make sure your doctor knows if you are allergic to codeine.
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
- If you take this medicine for more than a few weeks: Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- It is against the law and dangerous for anyone else to use your medicine. Keep your medicine in a safe and secure place so no one can steal it.
- Do not take too much of this medicine. This can be life-threatening. Symptoms of an overdose include: Extreme dizziness or weakness, shortness of breath, slow heartbeat, seizures, and cold, clammy skin. Call your doctor right away if you notice these symptoms.
- Call your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.
- This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Dark-colored urine or pale stools
- Extreme weakness, shallow breathing, uneven heartbeat, sweating, or cold or clammy skin
- Lightheadedness, dizziness, or fainting
- Nausea, vomiting, loss of appetite, or pain in the upper stomach
- Trouble breathing
- Yellowing of your skin or the whites of your eyes
If you notice these less serious side effects, talk with your doctor:
- Mild lightheadedness, sleepiness, or drowsiness
- Mild nausea or vomiting
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088