Dapiprazole Ophthalmic 

(da' pi pray zole)

IMPORTANT WARNING:

Dapiprazole ophthalmic is no longer available in the U.S. If you are currently using dapiprazole ophthalmic, you should call your doctor to discuss switching to another treatment.

WHY is this medicine prescribed?

Dapiprazole causes the pupil of the eye to constrict. It reverses pupil dilation caused by other drugs given during an eye examination.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

HOW should this medicine be used?

Dapiprazole comes as eyedrops. Usually, 2 drops are applied following an eye examination, and 2 more drops are applied 5 minutes later. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use dapiprazole exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

To use the eyedrops, follow these instructions:

  • Wash your hands thoroughly with soap and water.
  • Use a mirror or have someone else put the drops in your eye.
  • Shake the container well.
  • Remove the protective cap. Make sure that the end of the dropper is not chipped or cracked.
  • Avoid touching the dropper tip against your eye or anything else.
  • Hold the dropper tip down at all times to prevent drops from flowing back into the bottle and contaminating the remaining contents.
  • Lie down or tilt your head back or lie down and gaze upward.
  • Holding the bottle between your thumb and index finger, place the dropper tip as near as possible to your eyelid without touching it.
  • Brace the remaining fingers of that hand against your cheek or nose.
  • With the index finger of your other hand, pull the lower lid of the eye down to form a pocket.
  • Drop the prescribed number of drops into the pocket made by the lower lid and the eye. Placing drops on the surface of the eyeball can cause stinging.
  • Close your eye and press lightly against the lower lid with your finger for 2-3 minutes to keep the medication in the eye. Do not blink.
  • Replace and tighten the cap right away. Do not wipe or rinse it off.
  • Wipe off any excess liquid from your cheek with a clean tissue. Wash your hands again.
  • What SPECIAL PRECAUTIONS should I follow?

    Before using dapiprazole eyedrops,

    • tell your doctor and pharmacist if you are allergic to dapiprazole or any other drugs.
    • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially other eye medications, and vitamins.
    • tell your doctor if you have eye problems or allergies.
    • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using dapiprazole, call your doctor immediately.
    • if you are using another eyedrop medication, use the eye medications at least 10 minutes apart.

    What should I do IF I FORGET to take a dose?

    Apply the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not apply a double dose to make up for a missed one.

    What SIDE EFFECTS can this medicine cause?

    Dapiprazole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • stinging, burning, or redness of the eye

    • tearing

    If you experience any of the following symptoms, stop using dapiprazole and call your doctor immediately:

    • blurred or unstable vision, especially at night
    • skin rash

    • itching

    • pain

    • swelling around the eyes
    • headache

    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

    What should I know about STORAGE and DISPOSAL of this medication?

    Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). If the eyedrop solution becomes cloudy or contains particles, do not use it; obtain a fresh bottle. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

    What OTHER INFORMATION should I know?

    Keep all appointments with your doctor. Your doctor will order certain eye tests to check your response to dapiprazole.

    Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Brand Names
    • Rev-Eyes®[¶]

    This branded product is no longer on the market. Generic alternatives may be available.

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