Ceftaroline Injection 

(sef tar' oh leen)

WHY is this medicine prescribed?

Ceftaroline injection is used to treat some types of skin infections and pneumonia (lung infection) caused by certain bacteria. Ceftaroline is in a class of medications called cephalosporin antibiotics. It works by killing bacteria.

Antibiotics such as ceftaroline injection will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

HOW should this medicine be used?

Ceftaroline injection comes as a powder to be added to fluid and given through a needle or catheter placed in your vein. It is usually injected intravenously (into a vein) over a period of 5 to 60 minutes twice a day (once every 12 hours) for 5 to 14 days. The length of your treatment depends on the type of infection you have and how your body responds to the medication.

You may receive ceftaroline injection in a hospital or you may give the medication at home. If you will be using ceftaroline injection at home, your healthcare provider will show you how to use the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions. .

You should begin to feel better during the first few days of your treatment with ceftaroline injection. If your symptoms do not improve or get worse, call your doctor.

Use ceftaroline injection until you finish the prescription, even if you feel better. If you stop using ceftaroline injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Are there OTHER USES for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before using ceftaroline injection,

  • tell your doctor and pharmacist if you are allergic to ceftaroline; other cephalosporin antibiotics such as cefaclor, cefadroxil,cefazolin (Ancef, Kefzol), cefdinir, cefditoren (Spectracef), cefepime (Maxipime), cefixime (Suprax), cefotaxime (Claforan), cefotetan, cefoxitin (Mefoxin), cefpodoxime, cefprozil, ceftazidime (Fortaz, Tazicef, in Avycaz), ceftibuten (Cedax), ceftriaxone (Rocephin), cefuroxime (Zinacef), and cephalexin (Keflex); penicillin antibiotics; carbapenem antibiotics; or any other medications. Ask your doctor or pharmacist if you are not sure if a medication you are allergic to belongs to one of these groups of medications. Also tell your doctor if you are allergic to any of the ingredients in ceftaroline injection. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had kidney disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using ceftaroline injection, call your doctor.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do IF I FORGET to take a dose?

Use the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not use a double dose to make up for a missed one.

What SIDE EFFECTS can this medicine cause?

Ceftaroline injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • diarrhea
  • constipation

• nausea

  • vomiting
  • redness or irritation at the injection site

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • watery or bloody stools, stomach cramps or fever during treatment or for up to two or more months after stopping treatment

• hives

• rash

• itching

  • difficulty breathing or swallowing
  • swelling of the tongue or throat
  • extreme tiredness
  • pale skin
  • fast or irregular heartbeat
  • shortness of breath
  • chest pain
  • dizziness
  • cold hands and feet

Ceftaroline may cause other side effects. Call your doctor if you have any unusual problems while using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about STORAGE and DISPOSAL of this medication?

Your healthcare provider will tell you how to store your medication. Store your medication only as directed. Make sure you understand how to store your medication properly.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

What should I do in case of OVERDOSE?

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to ceftaroline injection.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking ceftaroline injection.

Do not let anyone else use your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish your treatment with ceftaroline injection, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand Names
  • Teflaro®

Please note, not all procedures included in this resource library are available at Henry Ford Allegiance Health or performed by Henry Ford Allegiance Health physicians.

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