Clonidine 

(kloe' ni deen)

WHY is this medicine prescribed?

Clonidine is used alone or in combination with other medications to treat high blood pressure. Clonidine is in a class of medications called centrally acting alpha-agonist hypotensive agents. It works by decreasing your heart rate and relaxing the blood vessels so that blood can flow more easily through the body.

HOW should this medicine be used?

Clonidine comes as a tablet to take by mouth. It is usually taken two or three times a day at evenly spaced intervals. Take clonidine at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take clonidine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may start you on a low dose of clonidine and gradually increase your dose, not more than once every week.

Clonidine controls high blood pressure but does not cure it. Continue to take clonidine even if you feel well. Do not stop taking clonidine without talking to your doctor. If you suddenly stop taking clonidine, it can cause a rapid rise in your blood pressure and symptoms such as nervousness, headache, and uncontrollable shaking of a part of the body. Your doctor will probably decrease your dose gradually over 2 to 4 days.

Are there OTHER USES for this medicine?

Clonidine is also used in the treatment of dysmenorrhea (severely painful cramps during menstrual period), hypertensive crisis (a condition in which your blood pressure is very high), Tourette's syndrome (a condition characterized by the need to perform repeated motions or to repeat sounds or words), attention deficit hyperactivity disorder (ADHD), menopausal hot flashes, and alcohol and opiate (narcotic) withdrawal. Clonidine is also used and as an aid in smoking cessation therapy and to diagnose pheochromocytoma (a tumor that develops on a gland near the kidneys and may cause high blood pressure and fast heart rate). Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before taking clonidine,

  • tell your doctor and pharmacist if you are allergic to clonidine, any of its ingredients, clonidine patches, or any other medications. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants; beta blockers such as acebutolol (Sectral), atenolol (Tenormin, in Tenoretic), betaxolol (Kerlone), bisoprolol (Zebeta, in Ziac), carvedilol (Coreg), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard, in Corzide), pindolol, propranolol (Inderal, Innopran XL, in Inderide), sotalol (Betapace, Sorine), and timolol (Blocadren, in Timolide); calcium channel blockers such as amlodipine (Norvasc, in Caduet and Lotrel), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Plendil, in Lexxel), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular), and verapamil (Calan, Isoptin, Verelan, others); digoxin (Digitek, Lanoxicaps, Lanoxin); medications for anxiety, mental illness, or seizures; sedatives; sleeping pills; tranquilizers; and tricyclic antidepressants such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), maprotiline, nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had a stroke, a recent heart attack, or heart or kidney disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking clonidine, call your doctor.
  • talk to your doctor about the risks and benefits of using clonidine if you are 65 years of age or older. Older adults should not usually use clonidine because it is not as safe as other medications that can be used to treat the same condition.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking clonidine.
  • you should know that clonidine may make you drowsy or dizzy. Do not drive a car or operate machinery until you know how this medication affects you.
  • ask your doctor about the safe use of alcohol while you are taking clonidine. Alcohol can make the side effects from clonidine worse.
  • you should know that clonidine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking clonidine. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

What SPECIAL DIETARY instructions should I follow?

Your doctor may prescribe a low-salt or low-sodium diet. Follow these directions carefully.

What should I do IF I FORGET to take a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What SIDE EFFECTS can this medicine cause?

Clonidine may cause side effects. Tell your doctor if any of these symptoms or those listed in the SPECIAL PRECAUTIONS section, are severe or do not go away:

  • dry mouth
  • tiredness
  • weakness
  • headache
  • nervousness
  • decreased sexual ability

• nausea

  • vomiting
  • constipation

If you experience any of the following symptoms, call your doctor immediately:

  • rash anywhere on the body

• hives

  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • difficulty swallowing or breathing
  • hoarseness

Clonidine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

What should I do in case of OVERDOSE?

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include the following:

  • fainting
  • slow heart rate
  • difficulty breathing
  • shivering
  • slurred speech
  • tiredness
  • confusion
  • cold, pale skin
  • drowsiness
  • weakness
  • smaller pupils (black circles in the middle of the eyes)

What OTHER INFORMATION should I know?

Keep all appointments with your doctor. Your blood pressure should be checked regularly to determine your response to clonidine.

Your doctor may ask you to check your pulse (heart rate) daily and will tell you how rapid it should be. Ask your doctor or pharmacist to teach you how to take your pulse. If your pulse is slower or faster than it should be, call your doctor before taking this medication that day.

To relieve dry mouth caused by clonidine, chew gum or suck sugarless hard candy.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand Names
  • Catapres®
  • Jenloga®[¶]
  • Kapvay®
  • Clorpres® (as a combination product containing Chlorthalidone, Clonidine)
  • Combipres® (as a combination product containing Chlorthalidone, Clonidine)[¶]
  • Also available generically

This branded product is no longer on the market. Generic alternatives may be available.

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