Clomiphene 

(kloe' mi feen)

WHY is this medicine prescribed?

Clomiphene is used to induce ovulation (egg production) in women who do not produce ova (eggs) but wish to become pregnant (infertility). Clomiphene is in a class of medications called ovulatory stimulants. It works similarly to estrogen, a female hormone that causes eggs to develop in the ovaries and be released.

HOW should this medicine be used?

Clomiphene comes as a tablet to take by mouth. It is usually taken once a day for 5 days, beginning on or about day 5 of the cycle. To help you remember to take clomiphene, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take clomiphene exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Are there OTHER USES for this medicine?

Clomiphene is also sometimes used to treat male infertility, menstrual abnormalities, fibrocystic breasts, and persistent breast milk production. Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before taking clomiphene,

  • tell your doctor and pharmacist if you are allergic to clomiphene or any other medications.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking.
  • tell your doctor if you have or have ever had liver disease, ovarian cysts (except those from polycystic ovary syndrome), uterine fibroids, abnormal vaginal bleeding, a pituitary tumor, or thyroid or adrenal disease.
  • tell your doctor if you are pregnant or breast-feeding. If you become pregnant while taking clomiphene, call your doctor immediately.
  • you should know that clomiphene may cause blurred vision. Do not drive a car or operate machinery, especially in poor lighting, until you know how this medication affects you.
  • you should know that clomiphene increases the chance of multiple pregnancy (twins or more). Talk to your doctor about the risks of multiple pregnancy.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do IF I FORGET to take a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, call your doctor for additional directions. Do not take a double dose to make up for a missed one.

What SIDE EFFECTS can this medicine cause?

Clomiphene may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • flushing (feeling of warmth)
  • upset stomach
  • vomiting
  • breast discomfort
  • headache
  • abnormal vaginal bleeding

Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:

  • blurred vision
  • visual spots or flashes
  • double vision
  • stomach or lower stomach pain
  • stomach swelling
  • weight gain
  • shortness of breath

Long-term use of clomiphene may increase the risk of ovarian cancer. Clomiphene should not be used for more than about six cycles. Talk to your doctor about the risks of taking this medication.

Clomiphene may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

What should I do in case of OVERDOSE?

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

  • upset stomach
  • vomiting
  • hot flashes
  • blurred vision
  • visual spots or flashes
  • blind spots
  • stomach swelling
  • stomach or lower stomach pain

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and laboratory. Your doctor may order certain lab tests to check your body's response to clomiphene.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand Names
  • Clomid®
  • Milophene®[¶]
  • Serophene®
  • Also available generically

This branded product is no longer on the market. Generic alternatives may be available.

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