Deferiprone 

(de fer' i prone)

IMPORTANT WARNING:

Deferiprone may cause a decrease in the number of white blood cells made by your bone marrow. White blood cells help your body fight infection, so if you have a low number of white blood cells, there is a higher risk that you will develop a serious or life-threatening infection. Tell your doctor about all the medications you are taking, because taking certain other medications along with deferiprone may increase the risk that your white blood cell count will decrease. If you experience any of the following symptoms of infection, stop taking deferiprone and call your doctor immediately or get emergency medical help: fever, sore throat, mouth sores, flu-like symptoms, chills, or severe shaking.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain laboratory tests, including tests to check your white blood cell count before your treatment and at least once weekly during your treatment.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with deferiprone and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Talk to your doctor about the risk(s) of taking deferiprone.

WHY is this medicine prescribed?

Deferiprone is used to remove excess iron in the body in people who have received a large number of blood transfusions to treat thalassemia (an inherited condition that causes a low number of red blood cells) and who have not benefitted enough from other treatments for excess iron. Deferiprone is in a class of medications called iron chelators. It works by attaching to iron in the body so that it can be excreted (removed from the body).

HOW should this medicine be used?

Deferiprone comes as a tablet to take by mouth. It is usually taken three times a day, in the morning, at mid-day, and in the evening. Deferiprone may be taken with or without food, but taking it with meals may help to prevent nausea that may be caused by the medication. Take deferiprone at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take deferiprone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If your dose includes half of a tablet, split a tablet carefully on the score mark.

Your doctor may adjust your dose of deferiprone every 2 to 3 months depending on your laboratory test results.

Are there OTHER USES for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before taking deferiprone,

  • tell your doctor and pharmacist if you are allergic to deferiprone, any other medications, or any of the ingredients in deferiprone tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention diuretics (water pills). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • if you are taking antacids, multivitamins, or iron or zinc supplements, take them 4 hours before or 4 hours after you take deferiprone.
  • tell your doctor what herbal products you are taking, especially milk thistle.
  • tell your doctor if you have or have ever had a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death), a slow heartbeat, heart failure or other heart problems, a low level of potassium or magnesium in your blood, or kidney or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should use birth control so that you will not become pregnant during your treatment with deferiprone. Talk to your doctor about which method of birth control you should use. If you become pregnant while taking deferiprone, call your doctor immediately. Deferiprone may harm the fetus.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do IF I FORGET to take a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What SIDE EFFECTS can this medicine cause?

Deferiprone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nausea

  • vomiting
  • heartburn
  • stomach pain
  • diarrhea
  • increased or decreased appetite
  • weight gain
  • pain in the arms, legs, back or joints
  • headache
  • red or brown discoloration of urine

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

  • reddish purple spots or rash, especially on the lower half of the body

• hives

  • swelling around the eyes
  • fast or pounding heartbeat
  • dizziness
  • lightheadedness
  • fainting
  • seizures

Deferiprone may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

What should I do in case of OVERDOSE?

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order lab tests to check your body's response to deferiprone.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand Names
  • Ferriprox

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