Ewing Sarcoma

Definition

Ewing sarcoma is a type of bone cancer. The most commonly affected areas include the pelvis, thigh, lower leg, upper arm, and chest wall.

Leg and Pelvic Bones—Common Sarcoma Sites
Leg bones
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Causes

Cancer is when cells in the body split without control or order. These cells go on to form a growth or tumor. The term cancer refers to harmful growths. These growths attack nearby tissues. They also spread to other parts of the body. It’s not clear exactly what causes these problems. It’s likely a mix of genes and the environment.

Risk Factors

Risk factors are not clear since the cause is unknown. This type of cancer is more common in male teenagers who are White. But it can happen at any age.

Symptoms

Symptoms will depend on where the tumor is. General symptoms may include:

  • Pain which:
    • May come and go or be constant
    • Range from mild to severe
    • May include feeling of pins and needles
  • Redness and swelling around the area
  • Fatigue
  • Fever
  • Weight loss and reduced appetite
  • Broken bone with no known cause

Diagnosis

The doctor will ask about your symptoms and health history. A physical exam will also be done. There are a number of bone issues that cause the same symptoms. Tests will help to confirm Ewing sarcoma.

The doctor will do a biopsy. A sample of tissue will be removed from the area. A lab will look for cancer cells.

Bone Biopsy
Bone biopsy
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Image tests will show the size and location of the tumor. Tests may include:

The doctor may also order blood tests. It will help to show if bone tissue was damaged.

Treatment

The goal of treatment is to remove or kill as much of the cancer as possible. Treatment will be based on tumor size and location but often includes a combination of:

Chemotherapy

Chemotherapy drugs are used to kill tumor cells. Your doctor will prescribe a combination of drugs to be given over a set time. This usually means every 2-4 weeks for several months.

This is often the first step in treatment. It may help to shrink the tumor before other treatment. It can also attack tumors that may have spread to other areas of the body.

Surgery

The tumor may be removed with surgery. It is often done after chemotherapy to try to shrink the tumor first.

The bone may need repair after the tumor is removed. A bone graft or prosthesis may be needed to support the remaining bone. It may take a number of surgeries to get full use of the limb.

Radiation Therapy

Radiation therapy uses high-energy x-rays to kill tumor cells. It can help shrink tumors before a surgery. It may also be used instead of surgery. It is often given over several weeks.

Future Therapy

A high-dose chemotherapy is being tested for ewing sarcoma. This high dose kills off bone marrow. A stem cell transplant is then needed to help grow healthy bone marrow. This combination therapy is typically used in cases where the tumor is resistant.

Prevention

There is no way to prevent Ewing sarcoma since the cause is unknown.

Revisions

Please note, not all procedures included in this resource library are available at Henry Ford Allegiance Health or performed by Henry Ford Allegiance Health physicians.

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