(ka'' boe zan' ti nib)


Cabozantinib may cause you to develop a fistula (abnormal connection between 2 organs inside your body, or between an organ and the outside of your body) or a tear in the wall of your stomach or intestine. These conditions are serious and may be life-threatening. Call your doctor immediately if you experience severe stomach pain or if you begin to cough, gag, or choke, especially while you are eating or drinking.

Cabozantinib may cause serious or life-threatening bleeding. Tell your doctor if you have recently had any episodes of unusual or heavy bleeding and if you have been coughing up blood. If you experience any of the following symptoms, call your doctor immediately: coughing up blood or blood clots, vomiting material that is bloody or that looks like coffee grounds, blood in stool, black and tarry stools, heavy menstrual bleeding, or other unusual bruising or bleeding.

Talk to your doctor about the risks of taking cabozantinib.

WHY is this medicine prescribed?

Cabozantinib is used to treat a certain type of thyroid cancer that is getting worse and that has spread to other parts of the body. Cabozantinib is in a class of medications called tyrosine kinase inhibitors. It works by slowing or stopping the growth of cancer cells.

HOW should this medicine be used?

Cabozantinib comes as a capsule to take by mouth. It is usually taken once a day on an empty stomach, at least 1 hour before and 2 hours after eating. Take cabozantinib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take cabozantinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole with a full glass (8 ounces, 240 mL) of water. Do not split, chew, or crush them.

Your doctor may decrease your dose of cabozantinib or tell you to stop taking the medication for a time or permanently if you experience serious side effects. Be sure to talk to your doctor about how you are feeling during your treatment with cabozantinib.

The length of your treatment depends on how well you respond to the medication and the side effects you experience. Continue to take cabozantinib even if you feel well. Do not stop taking cabozantinib without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Are there OTHER USES for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before taking cabozantinib,

  • tell your doctor and pharmacist if you are allergic to cabozantinib, any other medications, or any of the ingredients in cabozantinib capsules. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: antifungals such as ketoconazole (Nizoral), itraconazole (Sporanox), and voriconazole (Vfend); clarithromycin (Biaxin); dexamethasone; certain medications for HIV or AIDS such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); certain medications for seizures such as carbamazepine (Tegretol, Equetro), phenobarbital, and phenytoin (Dilantin); nefazodone; rifabutin (Mycobutin); rifampin (Rifadin, Rifactin, in Rifamate, in Rifater); rifapentin (Priftin); and telithromycin (Ketek). Many other medications may also interact with cabozantinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you more carefully for side effects.
  • tell your doctor what herbal products you are taking, especially St. John's wort.
  • tell your doctor if you have an open wound and if you have or have ever had high blood pressure or liver disease.
  • tell your doctor if you or your partner is pregnant or plans to become pregnant. If you or your partner can become pregnant, you should use birth control during your treatment with cabozantinib and for 4 months after your treatment. If you or your partner becomes pregnant while you are taking cabozantinib, call your doctor immediately. Cabozantanib may harm the fetus.
  • if you are having surgery, tell the doctor or dentist that you are taking cabozantinib. Your doctor will probably tell you to stop taking cabozantinib at least 28 days before your surgery and will tell you when you should start taking the medication again after your surgery.
  • you should know that cabozantinib may cause serious problems with your jaw. A dentist should examine your teeth before you start to take cabozantinib and regularly during your treatment. Be sure to brush your teeth and clean your mouth properly while you are taking cabozantinib. Talk to your doctor before having any dental treatments while you are taking this medication. Your doctor will probably tell you to stop taking cabozantinib at least 28 days before dental surgery.
  • you should know that your blood pressure may increase during your treatment with cabozantinib. Your doctor will probably monitor your blood pressure during your treatment.

What SPECIAL DIETARY instructions should I follow?

Do not drink grapefruit juice or eat grapefruit or any foods or supplements that contain grapefruit or grapefruit juice while you are taking this medication.

What should I do IF I FORGET to take a dose?

If you remember more than 12 hours before your next scheduled dose, take the missed dose as soon as you remember it and take your next dose at the scheduled time. However, if you remember less than 12 hours before your next scheduled dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What SIDE EFFECTS can this medicine cause?

Cabozantinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • diarrhea
  • constipation
  • hemorrhoids

• nausea

  • vomiting
  • heartburn
  • change in ability to taste food
  • difficulty swallowing
  • redness, swelling, or pain in your mouth or throat
  • loss of appetite
  • tiredness or weakness
  • bone pain
  • muscle pain or spasms

• anxiety

  • numbness, burning, or tingling in the hands, arms, feet, or legs

• rash

  • dry skin
  • patchy thickening of the skin
  • redness, pain, swelling, or blistering on the palms or the soles
  • hair loss
  • hair color turning lighter or gray
  • voice changes or hoarseness

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

  • swelling or pain in the arms or legs
  • shortness of breath
  • lightheadedness or fainting
  • sweating
  • numbness or weakness of the face, arm, or leg on one side of your body
  • dizziness
  • difficulty with balance or coordination
  • sudden, severe headache
  • jaw pain
  • toothache
  • seizures
  • vision problems
  • confusion
  • difficulty thinking clearly
  • difficulty eating or drinking due to mouth sores or nausea and vomiting

Cabozantinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

What should I do in case of OVERDOSE?

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

  • memory loss
  • confusion
  • weight loss

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to cabozantinib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand Names
  • Cometriq®

Please note, not all procedures included in this resource library are available at Henry Ford Allegiance Health or performed by Henry Ford Allegiance Health physicians.

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